Implications of thyroid dysfunction on Liver enzymes

Dr Monali Rewatkar; Dr Arun Tadas; Sanjay Agrawal; Prayas Nimbarte

Volume : IX, Issue : III, March - 2020

Implications of thyroid dysfunction on Liver enzymes

Dr Monali Rewatkar, Dr Arun Tadas, Sanjay Agrawal, Prayas Nimbarte

Abstract :

BACKGROUND: The liver has an important role in thyroid hormone metabolism. Normal level of thyroid hormones also important for normal hepatic function [1].Thyroid disorders often accompany abnormal serum enzyme levels and disturbances in liver functions. Thyroid diseases may be associated with elevation of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase(ALP).[2] Thyroid hormones regulate the basal metabolic rate of all cells including hepatocytes, and hence, modulate hepatic function; the liver in turn metabolizes the thyroid hormones and regulates their systemic endocrine effects .[3] Thyroid dysfunction may perturb liver function .So, the objective of this study is to evaluate the changes in liver function in thyroid dysfunction. AIMS: Aim of the present study is to determine the biochemical markers of liver function test ie Aspartate transaminase (AST), Alanine transaminase (ALT) and Alkaline phosphatase (ALP) in patients with thyroid dysfunction and to evaluate the effect of altered thyroid hormones on liver function tests . Also to find their possible correlation ie Pearsons correlation between Liver specific enzymes & thyroid hormones in patients attending clinical biochemistry OPD at tertiary care Unit, IGGMC,Nagpur. Materials & Methods – This study include about 100 patients attending clinical Biochemistry OPD, IGGMC, Nagpur for routine thyroid test. Estimations of thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone (TSH) done & Liver specific enzymes like activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) estimated in all patients..Collected sample was analysed for liver enzymes, run on Autoanalyser EM 460 in clinical Biochemistry Laboratory,IGGMC,Nagpur. Thyroid tests was run on Elisa reader & washer . Serum values of Thyroid stimulating hormone (TSH), thyroxine (T4) and tri-iodo thyronine (T3) were assayed by ELISA tests and values were compared & correlated with Liver enzymes level .The data was analysed & Pearsons Correlation was obtained, p value <0.05 considered as significant. RESULTS: Results of our study shows Positive Pearsons correlation between TSH & Liver enzymes in thyroid dysfunction while there is Negative Pearsons correlation between T3,T4 with Liver enzymes. P value is found to be statistically significant ie <0.05 . CONCLUSIONS: Thyroid dysfunction patients should be regularly checked for biochemical parameters of Liver enzymes. It can be concluded that thyroid hormones altered liver function tests. It is thus recommended that liver function tests interpretation in thyroid dysfunction must be advised to prevent progression of disease.