IMMUNOLOGIC AND GENETIC ASPECTS OF RECURRENT PREGNANCY LOSS

Midhula MM; Sumitha Prabhu PS; Rajadeesh M; Dinesh Roy

Volume : VI, Issue : XII, December - 2017

IMMUNOLOGIC AND GENETIC ASPECTS OF RECURRENT PREGNANCY LOSS

Midhula Mm, Sumitha Prabhu Ps, Rajadeesh M, Dinesh Roy

Abstract :

Recurrent pregnancy loss (RPL) is a heterogeneous condition that has many possible causes including genetic, hormonal, metabolic, uterine anatomical, infectious, environmental, occupational and personal habits, thrombophilia or immune disorders. There is 10% to 20% of women experience a miscarriage throughout their reproductive period. Primary infection caused by TORCH and other infectious agents can cause RPL. The aim of the study was to find out chromosomal abnormality and quantify the extent of DNA damage by Cytokinesis Block Micronuclei (CBMN) assay along with evaluating role of infectious agent in pregnancy loss. The present study was carried out in 44 couples suffering from 2 or more pregnancy loss as study subject and 22 age matched healthy couples with atleast one child were selected as control for the study. The mean CBMN frequency of subjects was correlated with various risk factors. A significant increase in mean CBMN frequency among the study subjects along with risk factors is suggestive of increased risk towards recurrent pregnancy loss. The study demonstrated the role of microorganism in DNA damage and its effect on reproduction. Hence, all cases with RPL should be routinely screened for TORCH and other infection as early diagnosis and appropriate intervention will help in proper management of these cases. < clear="all" style="page-eak-before:always;mso-eak-type:section-eak" />