Homeostatic Model Assessment for Hyper Ammonemia- Harmonization between Krebs TCA Cycle and Krebs-Henselit Urea Cycle affected Ammonia Clearance in Liver Disease and Renal Failure.

Prof. K Goswami; I. Mazumdar; P. Pal; K. Sridhar

Volume : V, Issue : XI, November - 2016

Homeostatic Model Assessment for Hyper Ammonemia- Harmonization between Krebs TCA Cycle and Krebs-Henselit Urea Cycle affected Ammonia Clearance in Liver Disease and Renal Failure.

Prof. K Goswami, I. Mazumdar, P. Pal, K. Sridhar

Abstract :

Ammonia (NH3) levels fluctuate widely in patients with hepatic encephalopathy, and excess NH3 in ain leads to excessive accumulation of glutamine, which compromises astrocyte morphology and function accounting for the neurotoxicity induced complications, including altered consciousness and coma. Impaired renal function also causes both uremia and hyperammonemia, which seems to be the key substrate to diagnose encephalopathy. The present study estimates levels of blood NH3 in both hepatic and uremic encephalopathy, and whether any correlation exists with other parameters of encephalopathy. Cirrhotic Patients with Hepatic encephalopathy and Uremic encephalopathy were included in the study to estimate NH3, liver and renal function and serum electrolytes. NH3 showed significant difference between both patients and control groups. All other parameters showed significant variations in levels between cases and controls; except for Serum Urea and Calcium, which did not alter significantly in hepatic encehelopathy, and anions levels, which showed no significant changes in uremic encephalopathy.