Histopathological effects of Doxorubicin on liver and kidney of wistar albino rats.

Arish Nazir Shora; N.S Jamwal; Uzma Rasool

Volume : VI, Issue : VIII, August - 2017

Histopathological effects of Doxorubicin on liver and kidney of wistar albino rats.

Arish Nazir Shora, N. S Jamwal, Uzma Rasool

Abstract :

Introduction: - Ideal anticancer drugs should eradicate cancer cells without harming normal tissues. Unfortunately, no currently available agents meet these criteria, and clinical use of these drugs involves a weighing of their benefits against their toxicity in search for a favorable therapeutic index. Methods: - experimental animals were divided into 4 groups, control, low dose, therapeutic and high dose respectively. After giving respective doses and sacrificing the animals organs were taken and observed grossly and on under light microscopy. Result: - microscopic changes were observed in all groups except control group. Low dose group showed less change while therapeutic group showed most of the changes which were observed by other authors. High dose group showed marked toxic changes in organs like hemorrhages and congestion. Conclusion: - The present study showed that the toxicity pattern is almost same in low and therapeutic doses of doxorubicin, and this could be of immense value while treating the carcinoma patients while in high doses it cause severe toxicity on liver and kidneys.