High level of circulating platelet derived microvesicles in bone tumors

Volume : IV, Issue : IV, April - 2015

Judit Donath, Patricia Palfi, Bence Gyorgy, Gyula Poor, Miklos Szendroi, Agnes Kittel, Edit I Buzas, Andras Falus, Gyorgy Nagy

CoII, NiII, CuII and MnII complexes of Mannich base, as ligand, was prepared by condensation of aqueous semicarbazide,

morpholine and pyridine–3–carboxaldehyde. The structure of the newly synthesized Mannich base was investigated by

UV–Vis, IR, 1

H–NMR, 13C–NMR, molar conductance and magnetic susceptibility studies. The antimicrobial activities of the

ligand and metals complexes have been screened in vitro against the organisms E.faecalis, Proteus mirabilis, Bacillus cereus, E.aerogens, ESBL

E.coli, ESBL K.pneumoniae, by disc diffusion and well diffusion techniques. It is observed that the coordination of metal ions has pronounced

effect on the microbial activities of the ligand. The metal complexes have higher antimicrobial effect than the free ligand.