Hepatoprotective and Antioxidant Effects of Ficus Carica against Hepatotoxicity Induced by CCl4 in Rats

Kamel M.A.; El-Nabtity S.M.; Hazem T.I.

Volume : VI, Issue : XII, December - 2017

Hepatoprotective and Antioxidant Effects of Ficus Carica against Hepatotoxicity Induced by CCl4 in Rats

Kamel M. A. , El Nabtity S. M. , Hazem T. I.

Abstract :

In the view of presumably hepatoprotective potential, effects of water and ether extract of fruits of Ficus carica L. (Moraceae) on some serum biochemical parameters, some antioxidant enzymes and liver histopathological picture on CCl₄induced hepatotoxicity in male albino rats were scrutinized. The results had shown significant reduction in enzymatic values of AST, ALT, ALP, GGT, total bilirubin and lipid peroxidation level (LPO) in liver homogenate in both water extracts of Ficus carica (WEF) and ether extracts of Ficus carica (EEF) treated groups when compared to the CCl₄administered group. Moreover, total protein, albumin and globulin levels were significantly increased plus antioxidant scavenging capacity was restored through a significant elevation in reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) activities in liver tissue homogenates in comparison to CCl₄ administered rats. It was clear from the documented results that Ficus carica boasts a hepatoprecautionary role against experimentally induced liver cirrhosis by CCl₄.