Hemostasis in Hypertension - A Pivot role Blood Platelets, PT & aPT

Dr Prafful Kumar; Dr Shweta; Dr Abrar Hassan

Volume : VIII, Issue : I, January - 2019

Hemostasis in Hypertension - A Pivot role Blood Platelets, PT & aPT

Dr Prafful Kumar, Dr Shweta, Dr Abrar Hassan

Abstract :

Introduction : Hypertension the most recognized risk factor for coronary artery disease, cereovascular diseases & renal diseases, is the root cause of 7.6million premature deaths in people aged above 25years. Atherosclerosis MAY be cause of abnormal cascade in blood coagulation following MI or CVD. Present study determines the role of blood parameters like platelets count, prothrombin time & activated partial thromboplastin time in hypertensive patients as an AID in prevention of coagulopathy & thereby CAD & stroke. MATERIALS & METHODS: Inclusion criteria : 1. Test group-40 males hypertensive patients 38-60yrs males. 2. 2.Control group- 40 age & sex-matched normotensive subjects. Exclusion criteria: TY2DM, TB,CLOTTING DISEASES , ANTIPLATELETS MEDICATION, chronic illness & any infections. -BP recording: by manual sphygmomanometer Written consent was taken .-Lab. Analysis Hemostatic XF 2.0 & Horiba pentra XL 80. Statistical analysis: Student t test ( unpaired) Results: Prothrombin time & partial activated thromboplastin provides an effective insight about the Physiology of hemostatic and its pathology ( Hypercoagulability). Blood platelets are most compelling parameters in monitoring thrombosis. In present study Platelets count, prothrombin time & activated partial thromboplastin are ELEVATED in hypertensive subject compared with that of normotensive subjects.Conclusion: Hypertension is a risk factor for thrombotic diseases like stroke & CAD due to associated hemostatic dysfunction promoting coagulopathy