HEMO-LITH: CORRELATION BETWEEN IRON DEFICIENCY ANEMIA AND CHOLELITHIASIS USING COMPLETE BLOOD COUNTS AS THE SOLE GUIDE-A CASE CONTROL STUDY

Dr. Kalpit Goriwal; Dr. Neel Shah; Dr. Adheesh Goriwal

Volume : VII, Issue : X, October - 2018

HEMO-LITH: CORRELATION BETWEEN IRON DEFICIENCY ANEMIA AND CHOLELITHIASIS USING COMPLETE BLOOD COUNTS AS THE SOLE GUIDE-A CASE CONTROL STUDY

Dr. Kalpit Goriwal, Dr. Neel Shah, Dr. Adheesh Goriwal

Abstract :

IRON DEFICIENCY ANEMIA HAS BEEN IMPLICATED AS ONE OF THE FACTORS IN THE PATHOGENESIS OF CHOLELITHIASIS. MICRONUTRIENTS SUCH AS IRON, ZINC, COPPER, ETC HAVE BEEN SHOWN TO BE ASSOCIATED WITH CHOLELITHIASIS. IRON IS A CO-FACTOR FOR THE ENZYME NITRIC OXIDE SYNTHASE (NOS) WHICH IS RESPONSIBLE FOR THE PRODUCTION OF NITRIC OXIDE. REDUCED LEVELS OF NITRIC OXIDE ARE ASSOCIATED WITH DYSMOTILITY OF GALL BLADDER WALL. ALSO, IRON DEFICIENCY HAS BEEN SEEN TO BE ASSOCIATED WITH BILE SUPER SATURATION IN GALLBLADDER. WE HAVE RECONFIRMED THIS ASSOCIATION WITH CASE CONTROL STUDY MODEL, USING ONLY COMPLETE BLOOD COUNT PARAMETERS TO DEFINE IRON DEFICIENCY ANEMIA. THIS HAS AVOIDED EXTRA FINANCIAL BURDEN ON THE PATIENTS WHICH IS OF UTMOST IMPORTANCE IN THE REGION WITH COMPROMISED SOCIO-ECONOMIC STATISTICS.