Hematological, bone marrow and cytogenetics characterization in myelodyasplastic syndromes

Bibhuti Bhusan Prasad; Subhash Chandra Jha; Guari Shanker Lal

Volume : VIII, Issue : IV, April - 2019

Hematological, bone marrow and cytogenetics characterization in myelodyasplastic syndromes

Bibhuti Bhusan Prasad, Subhash Chandra Jha, Guari Shanker Lal

Abstract :

Myelodysplastic syndromes (MDS), also known as myelodysplastic neoplasms, are clonal disorders characterized by a maturational defect in bone marrow progenitor cells,ineffective hematopoiesis with peripheral cytopenia(s), and clonal cytogenetic change with an enhanced risk of transformation to secondary acute myeloid leukemia. CBC , PBS , Bone marrow aspiration , bone marrow biopsy and cytogenetic findings of 10 cases of MDS were collected and studied. MDS is major health problem in old population and diagnosis is challenge because hematopathologist could not give even provisional diagnosis unless until proper clinical note and differential diagnoses are not written in prescription. CBC , PBS , bone marrow aspiration, biopsy and cytogenetics are complimentary to each other.