HAEMODYNAMIC AND ANALGESIC PROFILE OF DIFFERENT DOSES OF CLONIDINE WITH SMALL DOSE OF BUPIVACAINE UNDER SPINAL ANAESTHESIA IN LOWER ABDOMINAL SURGERIES.

Sonali Beniwal; Pratibha Rathore

Volume : VI, Issue : XII, December - 2017

HAEMODYNAMIC AND ANALGESIC PROFILE OF DIFFERENT DOSES OF CLONIDINE WITH SMALL DOSE OF BUPIVACAINE UNDER SPINAL ANAESTHESIA IN LOWER ABDOMINAL SURGERIES.

Sonali Beniwal, Pratibha Rathore

Abstract :

Objective : To find out the lowest possible dose of Clonidine that can prolong the duration of sensory and motor anesthesia & analgesia with minimal dose of Bupivacaine without undue side effects. Methods : In this prospective randomized double blind study 90 ASA grade 1 & 2 patients were randomly allocated in 3 groups. All receive 6 mg Bupivacaine with 15ug of Clonidine in group 1, 45ug of Clonidine in Group 2 , 75ug of Clonidine in group 3 . Result : Onset of sensory analgesia & motor blockade up to maximal level was achieved faster with 75ug dose (sensory 9.6 � 0.67 min & motor 13.63 � 0.45 min) . The addition of Clonidine to Bupivacaine and increasing its dose delays the time for 2 segment sensory regression (149. �3.61min) , regression to segment L1 (246.72�2.58 min), increases the duration of motor blockade (200.83�2.73 min) & time to walking (320.83 �3.18min) & voiding (392.47�3.53min). It also increases the time to 1^st analgesic requested (339�3.32min). The incidence of postoperative complications was not significantly different in between different doses of Clonidine. Conclusion : 75ug is the preferred dose , in terms of effect versus side effects , when prolongation of spinal anesthesia is desired as in lower abdominal surgeries.