Volume : VII, Issue : IV, April - 2018

Genetic Insights into Congenital Heart Disease

Dr. Shubhangi Yadav

Abstract :

Congenital heart diseases (CHD)  are the most common type of birth defect and result in significant mortality worldwide. The etiology for the majority of these anomalies remains unknown but genetic factors are being recognized as playing an increasingly important role. There has been remarkable progress in understanding the genetic basis of cardiovascular malformations.Chromosome microarray analysis has provided a new tool to understand the genetic basis of syndromic cardiovascular malformations.Remarkable improvements in sequencing technology have led to easy testing for cardiomyopathy, single gene syndromic disorders, and Mendelian-inherited congenital heart disease. Understanding the genetic basis for these disorders has improved their clinical recognition and management and led to new guidelines for treatment and family-based diagnosis.                                                                               The aim  of this review is to provide the clinician with a summary of what is currently known about the contribution of genetics to the origin of congenital heart disease. It is expected that this summary will update a wide range of medical personnel, including pediatric cardiologists and pediatricians, adult cardiologists, obstetricians, and surgeons about the genetic aspects of congenital heart disease.

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Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Dr.Shubhangi Yadav, Genetic Insights into Congenital Heart Disease, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-7 | Issue-4 | April-2018

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