Formulation and Evaluation of Mouth Dissolving Tablets of CetrizinediHcl

Vivek D. Rathod; Abhijeet S Vaidya

Volume : VII, Issue : II, February - 2018

Formulation and Evaluation of Mouth Dissolving Tablets of CetrizinediHcl

Vivek D. Rathod, Abhijeet S Vaidya

Abstract :

Cetirizine hydrochloride (CTZ) is an orally active and selective H1-receptor antagonist used in seasonal allergic rhinitis, perennial allergic rhinitis and chronic urticaria. CTZ is a white, crystalline water soluble drug possessing bitter taste properties. Due to sore throat conditions, the patient experiences difficulty in swallowing a tablet type of dosage form. Thus, mouth fast dissolving tablets would serve as an ideal dosage form for the patients as well as paediatric patients who find it difficult to swallow the tablet. Advantages of this drug delivery system include administration without water. Some drug are absorbed from mouth, pharynx and esophagus as the saliva passes down in to the stomach and in such cases bioavailability of drug is increased, pre-gastric absorption can result in improved bioavailability and as a result to reduce dosage form, improved reduction of unwanted effects.