Expression of ER/PR in Thyroid Lesions with Special Reference to Papillary Carcinoma of Thyroid

Dr. Makbul Ansari; Dr. Asfa Ahmad; Dr. Gajendra Pandit; Prof. Dr. Raj Shekhar Sharma

Volume : IX, Issue : VIII, August - 2020

Expression of ER/PR in Thyroid Lesions with Special Reference to Papillary Carcinoma of Thyroid

Dr. Makbul Ansari, Dr. Asfa Ahmad, Dr. Gajendra Pandit, Prof. Dr. Raj Shekhar Sharma

Abstract :

Aims and Objectives: (i)Comparison of ER/PR positivity between neoplastic thyroid lesion. Materials and Method: Total 350 cases were taken. The specimen were examined externally and then opened as per conventional method.The tissues were processed as per standard procedure. Results: Out of 264 neoplastic cases 51 (19.3%) cases were ER+ and 74 (28%) cases were PR+. Expression of ER and PR between neoplastic and non-neoplastic groups was statistically significant.Out of 56 benign cases 7(12.5%) cases were ER + and 12 (21.4%) cases were PR +. Out of 208 malignant cases 44 (21.2%) cases were ER + and 62 (29.8%) cases were PR+. Maximum percentage of ER + (20.4%) and PR + (27.8%) cases were >4cm in size. ER expression was found in 32.1% of papillary carcinoma thyroid whereas PR expression was found in 35.2% of papillary thyroid carcinoma and 42.3% of medullary thyroid carcinoma. Conclusion: The study demonstrates that ER and PR expression occurs more frequently in neoplastic than in non-neoplastic lesions of thyroid. Papillary carcinoma and Medullary carcinoma of thyroid show significant expression of ER and PR receptors. ER/PR expression with various age groups, sex and size of tumour don�t show any statistical significance.