Experimental Evaluation Of Wound Healing Property Of Durvadi Oil In Wister Albino Rats

Dr. Sukrant Sharma; Dr. Ashanka Bhardwaj; Dr. Rajesh Yadav; Dr. Sarabjeet Kour

Volume : VIII, Issue : IX, September - 2019

Experimental Evaluation Of Wound Healing Property Of Durvadi Oil In Wister Albino Rats

Dr. Sukrant Sharma, Dr. Ashanka Bhardwaj, Dr. Rajesh Yadav, Dr. Sarabjeet Kour

Abstract :

Wound (vrana) means eak /destruction / rupture / discontinuity of body tissue / part of body. Sushruta samhita describes Vrana as the sign of the disease (lesion) which never disappears even after complete healing and as its imprint persist lifelong1. These descriptions match the description of a wound. Wound is a discontinuity or eak in the surface epithelium. Wound healing is a mechanism whereby the body attempts to restore the integrity of the injured part. Durvadi oil is a formulation mentioned in Bhaishajya ratnavali having healing property. This is an experimental study on Wistar albino rats to find out the healing effect of Durvadi oil.There were 3 groups- normal control, standard and test, each group containing 6 rats. In control group no intervention was done. In standard and Test group were treated with Povidone iodine ointment and Durvadi oil as an external medication respectively. Study was carried out for 24 days. Observational parameters included period of epithelialisation, percentage of wound contraction periodically, hydroxyproline estimation and histopathology assessed on 24th day. Period of epithelialisation was considerably reduced in test and standard group as compared to normal control group. Hydroxylproline estimation in the test group has shown significant decrease in the concentration as compared to normal control group. Histological examination showed better wound healing profile in reference standard and test drug applied group than normal control group. Wound area contraction rate was higher in test and standard group in comparison to normal control group.