Evaluation of Serum Uric Acid & its Association with Essential Hypertension in Normal Adults.

Dr Nazar Hussain

Volume : IX, Issue : VI, June - 2020

Evaluation of Serum Uric Acid & its Association with Essential Hypertension in Normal Adults.

Dr Nazar Hussain

Abstract :

Introduction: The association between serum uric acid and incidence of primary hypertension has gained widespread attention in the recent years. However, it is conjectural whether elevated uric acid is a risk factor, a mediator or merely a marker for hypertension in humans. Some clinical trials have shown that uric acid lowering agents are able to reduce blood pressure in adolescents, signifying that it might be an independent risk factor for hypertension. There are limited studies evaluating the relationship between increased uric acid levels and hypertension in the general healthy population in India. Objective: This study was conducted with an aim to evaluate the association between hypertension and raised uric acid level as an independent risk factor in adult population of North India. Results: There were a total of 200 subjects in our study of which 120 were males and the remaining were females. The mean age was 43.3 years for the males and 41.2 years for the females. The prevalence of hyperuricemia in our study was 29.5% (n=59), and 57.62% (n=34) of persons with increased uric acid levels had an abnormal blood pressure reading. Group I had 9 (4.5%) subjects with prehypertension compared to 27 (13.5%) cases in the group II. Conclusions: This study concludes that elevated serum uric acid levels are frequently associated with prehypertension and hypertension in general adult population, however there is a need of further studies especially in the Indian context to study the effect on severity and duration of hypertension with respect to uric acid levels.