EVALUATION OF SERUM CALCIUM, MAGNESIUM AND PHOSPHOROUS LEVELS IN SUBJECTS WITH HYPERTHYROIDISM

Dr. Sushma BJ; Dr. Shrikant Chandrakar

Volume : IX, Issue : IV, April - 2020

EVALUATION OF SERUM CALCIUM, MAGNESIUM AND PHOSPHOROUS LEVELS IN SUBJECTS WITH HYPERTHYROIDISM

Dr. Sushma Bj, Dr. Shrikant Chandrakar

Abstract :

Introduction: Thyroid hormones are essential for normal growth and maturation of skeleton, growth and maintenance of kidney function and plays an important role in maintenance of water and electrolyte homeostasis. On the other hand, kidney is involved in the metabolism and elimination of thyroid hormones. Thyroid hormone determines the mineral pool in the blood by influencing mobilization of minerals like calcium and phosphorous into the blood and by influencing their clearance through urinary excretion due to its effect on glomerular filtration rate (GFR) or renal plasma flow (RPF). Objectives of the study: To estimate TSH, T3, T4 levels in subjects with hyperthyroidism and healthy controls and to estimate and compare the serum levels of calcium, phosphorous and magnesium in subjects with hyperthyroidism and healthy controls. Materials and Methods: We included cases (hyperthyroidism) and healthy controls in the age group of 18- 60 years both males and females were included in the study. After taking informed consents, about 3 ml of venous blood was drawn using a disposable syringe under aseptic conditions in a sterile bulb from selected subjects. The serum was used for the analysis of calcium, magnesium and phosphorous by the spectrophotometric method on semi autoanalyzer using commercially available kits. Results: A total of 80 subjects were enrolled in the study, 40 cases of hyperthyroidism and 40 healthy controls. Out of 40, controls 7 were males, 33 were females and out of 40 cases 8 were males and 32 were females. There was highly significant decrease in TSH and magnesium, increase in T3, T4, Calcium, phosphorous levels in subjects with hyperthyroidism compared to healthy controls. There was no statistically significant correlation existed between TSH and serum calcium, phosphorous and magnesium levels in subjects with hyperthyroidism. Conclusion: Our study indicates the profound influence of thyroid hormone on mineral metabolism and changes in these minerals may eventually lead to complications like decreased bone mineral density and secondary osteoporosis. Therefore, it is necessary to evaluate the serum levels of these minerals in all patients with thyroid disorders.