Evaluation of platelet parameters in patients of ischemic heart disease and ischemic stroke.

Manvir Singh Tevatia; Krishna S Nair; Venkatesan Somasundaram

Volume : VIII, Issue : IX, September - 2019

Evaluation of platelet parameters in patients of ischemic heart disease and ischemic stroke.

Manvir Singh Tevatia, Krishna S Nair, Venkatesan Somasundaram

Abstract :

INTRODUCTION: Ischemic heart disease (IHD) and ischemic stroke are among the most common causes of morbidity worldwide. The aim of the current study is to evaluate the platelet parameters platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) and Platelet large cell ratio (P-LCR) as a risk factor in patients with IHD and ischemic stroke. MATERIALS AND METHODS: Study included 200 healthy controls and 200 cases of Acute coronary syndrome and ischemic stroke during the period of April 2017 to October 2017. Total platelet count, MPV, PDW, PCT and P-LCR of all these patients were obtained and compared with normal healthy controls. RESULTS: All indices excluding PLT and PCT were significantly raised among the cases (p<0.0001). The risk of a thrombotic event in the high P-LCR group was 1.89 times higher (p<0.05). Similarly, the risk of a thrombotic event in the high MPV group was 1.27 (p<0.05) times, and in the high PDW group was 1.11 times higher (p<0.05) than controls. There was negligible risk in cases that showed increased PCT and no risk in patients with high Platelet count. CONCLUSION: High MPV, PDW and P-LCR is associated with increased risk of development of ischemic events. Hence evaluation of these parameters in high risk patients can predict the possibility of an impending thrombotic event.