Evaluation of hypoglycemic effect of ethanolic leaf  extracts of Grewia Umbellifera

S. Gunasekaran; V.Srinivasan; R. Panneerselvam; S.Palani

Volume : IV, Issue : VIII, August - 2015

Evaluation of hypoglycemic effect of ethanolic leaf extracts of Grewia Umbellifera

S. Gunasekaran, V. Srinivasan, R. Panneerselvam, S. Palani

Abstract :

Grewia umbellifera is an Indian traditional medicinal plant of the Tiliaceae family .The present study was investigated for anti-diabetic of Grewia umbellifera in streptozotocin induced diabetes in rats. In the present study thirty rats were randomly classified into five groups. The first group was served as a control. The second group was served as Diabetic control. The third group was served as test 1 administered with 250 mg/kg and forth group was served as test 2 administered with 500 mg/kg of Ethanolic leaf extracts of Grewia umbellifera in a daily oral dose for 28 days. The fifth group was served as Standard (Glibenclamide 0.6 mg/ kg) Type II diabetes was induced in overnight fasted rats by a single intra peritoneal injection of 35mg/kg streptozotocin. Hyperglycemia was confirmed by the elevated glucose levels >250 mg dL-1 in plasma. Treatment of animals with ethanolic leaf extracts of Grewia umbellifera in a daily dose of 250 and 500 mg/kg for 28 consecutive days significantly mitigated the induced changes in the glucose and body weight parameters. Conclusively, ethanolic leaf extract of Grewia umbellifera treatment exhibited marked beneficial effects against streptozotocin induced diabetes.