Evaluation of Clinical Efficacy and Safety of Herbal formulation in Patients Suffering from Osteoarthritis of the Knee

Patil PT; Murthy MB

Volume : V, Issue : IV, April - 2016

Evaluation of Clinical Efficacy and Safety of Herbal formulation in Patients Suffering from Osteoarthritis of the Knee

Patil Pt, Murthy Mb

Abstract :

<p>Background: The present study was conducted to evaluate the clinical efficacy and safety of herbal formulation in patients suffering from osteoarthritis of the knee. Methodology: It was a prospective, open labeled, randomized active controlled study. The study was conducted in the outpatient Department of Orthopedics in a tertiary care hospital over duration of one year. 15 patients in PCT and 17 in HF group were enrolled. Numeric rating scale and symptom score were used as pain efficacy parameters. Self-reported adverse events were used to assess safety of the drugs and causality assessment was done using Naranjo&rsquo;s scale. Results: NRS score was significantly lower in the HF group as compared to PCT group at the end of therapy (p-0.0464*). There was no statistically significant improvement in the symptom score. On comparison, total number of adverse drug events reported in the two groups showed no statistical significance. Conclusion: Herbal formulation offers better symptomatic relief of pain and is well tolerated as PCT in patients of OA of knee.</p>