Volume : VI, Issue : VII, July - 2017

EVALUATION OF ACTIVITY OF PLATELETS IN DIABETES MELLITUS - A KEY ROLE IN DIAGNOSIS

Dr. Manoharan A, Dr. Ravichandran. S, Prof. Dr. Pammy Sinha, Prof. Dr. Jayalakshmi. G

Abstract :

 Introduction

Platelets or thrombocytes  are small, disc shaped clear cell fragments which measure 2–3 µm in diameter, which are derived from its precursor  megakaryocytes by fragmention.  They are anucleated cells which plays a vital  role in hemostasis and thrombosis. Platelets normally circulate in the bloodstream in a quiescent state, but it gets activated following damage to the vessel wall, leading to rapid formation of a platelet aggregate or vascular plug and occlusion of the site of damage. The morphological variations in assessing Mean Platelet Volume (MPV) have important implications for assessing the functional expressions of platelets. The activity of platelets can be very well observed in the mean platelet volume(MPV), which acts as as a marker of platelet activity. The MPV is affected by aging of platelets and varies according to the balance between production and destruction. Platelet count and  MPV are  strongly associated with prognosis in critically ill patients. Elevated MPV values are noted in uncontrolled diabetes mellitus (DM).

Objectives:

1.To compare the MPV values among diabetics along with healthy non-diabetic people.

2. To determine the age and sex group among diabetic and non-diabetic  patients.

Materials and Methods

The patients were classified as diabetic patients and non diabetic patients and mean platelet volume (MPV) were calculated. Totally 295 patients were taken for our study, out of which 180 were diabetic and 115 were non diabetic. Patient’s medical history was obtained. The parameters were analysed statistically.

Results

Among  diabetic patients, 120 patients were males and 60 patients were females and mean MPV was 11.0 fL. In 115 non-diabetic controls 82 patients were males and 33 patients were females and mean MPV was 9.5 fL. Among diabetics the mean age group was 55±5 and in non diabetics mean age group was 40±5. Among diabetic patients 30 patients(16.6%) showed clinical symptoms, in which they showed MPV higher than 11.5. 

Conclusion:

Mean platelet volume values are significantly elevated in uncontrolled diabetic patients when compared with non diabetic patients. And these patients with higher MPV will  be more prone for complications. So, by assessing MPV values we can predict the diabetic patients whether they are prone to severity or not. MPV can be considered as a prognostic marker for disease progression for diabetes.

Keywords :

Article: Download PDF    DOI : https://www.doi.org/10.36106/gjra  

Cite This Article:

Dr.Manoharan A, Dr. Ravichandran.S, Prof.Dr.Pammy Sinha, Prof.Dr.Jayalakshmi.G, EVALUATION OF ACTIVITY OF PLATELETS IN DIABETES MELLITUS‾A KEY ROLE IN DIAGNOSIS, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : VOLUME-6 | ISSUE‾7 | JULY -2017

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