EVALUATION AND ANALYSIS OF LIPID PROFILE IN PSORIASIS PATIENTS

Dr. Priyadarshini R Jadhav; Dr. Ganesh Dhavalshankh; Dr. Ranjeet Ranade; Dr. Archana Dhavalshankh

Volume : VI, Issue : XI, November - 2017

EVALUATION AND ANALYSIS OF LIPID PROFILE IN PSORIASIS PATIENTS

Dr. Priyadarshini R Jadhav, Dr. Ganesh Dhavalshankh, Dr. Ranjeet Ranade, Dr. Archana Dhavalshankh

Abstract :

Psoriasis is a chronic inflammatory skin disease that is associated with an increased cardiovascular risk profile. The underlying pathogenic mechanisms remain unclear. Multiple factors including systemic inflammation, oxidative stress, aberrant lipid profile and concomitant cardiovascular risk factors have been associated. Psoriasis has been associated with abnormal plasma lipid metabolism and oxidative stress. In this study, we emphasized on the serum lipid disturbances in psoriasis at various clinical stages.

The study was conducted at KLE Hospital and MRC, Belgaum in 40 subjects of psoriasis with age group of 20-70 years and 40 controls. Cases with history of diabetes, hypertension, obesity, family history of hyperlipidemia, intake of systemic drugs like lipid lowering agents, alcohol and smoking were excluded from the study.

Blood and urine samples were collected after obtaining proper consent from all cases and controls. Serum lipids were measured by enzymatic methods. Serum TC, LDL-C, TC/HDL-C ratio and LDL-C/HDL-C ratio were significantly higher in psoriasis patients compared to controls but no statistically significant difference in serum TG, HDL-C and VLDL-C. We conclude that pathogenic link may coexist between lipoprotein, oxidative stress and psoriatic pathophysiology. This provides valuable information for timely intervention.