ETIOLOGICAL PROFILE OF PRIMARY AMENORRHEA IN KASHMIR VALLEY

Zhahid Hassan; Rahat Abbas; Farhat Abbas; Mohsin Gayas

Volume : VIII, Issue : VI, June - 2019

ETIOLOGICAL PROFILE OF PRIMARY AMENORRHEA IN KASHMIR VALLEY

Zhahid Hassan, Rahat Abbas, Farhat Abbas, Mohsin Gayas

Abstract :

Background: Primary amenorrhoea is defined as absence of menstruation by the age of 14 in absence of secondary sexual characteristics and by age 16 regardless of the presence or absence of secondary sexual characteristics. The normal menstrual cycle involves complex interactions between the hypothalamic pituitary axis, the ovaries and the outflow tract, thus disruption at any level can result in abnormal menstruation and amenorrhea. Aims and objectives:To determine etiologic causes of primary amenorrhea in kashmeri population. Materials and methods: This is a prospective and observational study conducted in department of endocrinology at skims from jan 2015 to jan 2017.Cases were analysed according to clinical profile, development of secondary sexual characteristics, physical examination, relevant biochemical, hormonal and radiological investigations as indicated. Results: The three most common causes of primary amenorrhea were hypergonadotropic hypogonadism 40.50%, hypogonadotropic hypogonadism 34.17% and mullerian agenesis 12.65%.Turner syndrome and gonadal dysgenesis were common in hypergonadotropic hypogonadism and idiopathic gonadotropin deficiency and constitutional delay in growth and development were common in hypogonadotropic hypogonadism .