ESTIMATION OF ROLE OF SERUM HOMOCYSTEINE AND SERUM FOLATE IN PREECLAMPTIC WOMEN AT TERM PREGNANCY

DR. MOHINI PAUL; DR. ANNU DABLA

Volume : VII, Issue : VI, June - 2018

ESTIMATION OF ROLE OF SERUM HOMOCYSTEINE AND SERUM FOLATE IN PREECLAMPTIC WOMEN AT TERM PREGNANCY

Dr. Mohini Paul, Dr. Annu Dabla

Abstract :

Elevated plasma homocysteine and decreased serum folate level has been implicated in vascular changes and endothelial dysfunction caused by lipid peroxidation and formation of free radicles similar to those seen in preeclampsia. The aim of this study was to determine the levels of serum homocysteine in preeclamptic patients at term, to determine the levels of serum folate in preeclamptic patients at term and to study correlation between serum folate levels and serum homocysteine in preeclamptic patients at term.

Study design Prospective case control study of 50 preeclamptic patients that were age, parity and BMI matched with 50 controls of same gestational age. The preeclamptics were further divided into mild , 38 and severe preeclampsia ,12.

Results Mean levels of serum homocysteine were significantly elevated in the preeclamptic than in control group (9.45�2.68�mol/l v/s 4.99 � 0.96�mol/l respectively). Mean levels of serum folate were significantly reduced in the preeclamptic patients (9.28 � 1.96ng/ml v/s 15.48 � 2.47ng/ml). An inverse but statistically insignificant relation appeared between low serum folate and elevated serum homocysteine levels in the preeclamptic patients.

Conclusion From the present study it was concluded that serumhomocysteine levels were significantly elevated in patients with preeclampsia and serum folate levels were significantlydecreased when compared to control group. An inverse correlation was seen between serum folate levels and serum homocysteine levels in preeclamptic patients.