Estimate the prevalence of CKD and its risk factors in spouses and first degree relatives (FDR) of ESRD patients

Dr .CHADA RAMESH; Dr. VENKATESHWARLU RAJURI; Dr .SREEKANTH BURRI

Volume : VI, Issue : I, January - 2017

Estimate the prevalence of CKD and its risk factors in spouses and first degree relatives (FDR) of ESRD patients

Dr . Chada Ramesh, Dr. Venkateshwarlu Rajuri, Dr . Sreekanth Burri

Abstract :

BACKGROUND: Chronic kidney disease (CKD) is now recognized as a global public health challenge¹. CKD is defined as kidney damage or glomerular filtration rate (GFR) less than 60 ml/min per 1.73 /m² for 3 months or more, irrespective of cause CKD is classified into stages according to the level of GFR, and stage-specific action plans facilitate its evaluation and management^{5, 6, 7}

AIM: Estimate the prevalence of CKD in spouses and first degree relatives (FDR) of ESRD patients.

OBJECTIVE OF STUDY: To estimate glomerular filtration rate in the first degree relatives (FDRs) and spouses of patients with End stage renal disease (E.S.R.D) by various formulae.

STUDY DESIGN: Cross sectional observational study.

MATERIALS AND METHODS: This observation study was carried out in the Department of Nephrology at Gandhi medical college and CAIMS from January, 2014 to December, 2015.Firstdegree relatives and spouses of patients of ESRD disease were counseled about the risk of CKD and asked to volunteer for screening. We calculated eGFR using the equations:

STATISTICAL ANALYSIS: Statistical analysis was done using the SPSS package, version 20.0. Descriptive analysis was used to characterize the study population by its demographic (age, gender) medical history and investigations (history of hypertension, diabetes, serum creatinine, and e GFR). Results were expressed as mean � 1 SD done by ANOVA. Significance was considered for P < 0.05. Reliability test was performed and represented as Cronbach�s alpha. Cronbach�s α of more than 0.7 says that there is agreement and correlation between two measurements. The more the value the higher is the correlation.

RESULTS:

Total number of males and females found to be in stage 3 were higher based on CGF equation (10.1%) when compared to M.D.R.D (1.7%) and CKD-EPI (1.3%)

Significant numbers of subjects with hypertension are classified to stages 2 and 3 by C.G.F (62.73%), M.D.R.D (54.9%) and CKD-EPI (52.9%).

Significant numbers of subjects with diabetes are classified to stages 2 and 3 by C.G.F (89.6 %), M.D.R.D (68.4%) and CKD-EPI (68.4%).

Cronbach�s α is 0.711 indicating that both C.G.F and M.D.R.D correlated well.

Cronbach�s α is 0.729 indicating that both C.G.F and M.D.R.D correlated well.

CONCLUSIONS: High prevalence of stage 2 and 3 CKD found in both FDRs and spouses by all three equations where as stage 3 CKD is highly prevalent in spouses than in FDRs.