Efficacy of Neutrophil gelatinase associated lipocalin as an early marker of AKI in adult ICU patients

Dr. Rudach Mitul Devanand; Dr. V. Padma

Volume : VII, Issue : XI, November - 2018

Efficacy of Neutrophil gelatinase associated lipocalin as an early marker of AKI in adult ICU patients

Dr. Rudach Mitul Devanand, Dr. V. Padma

Abstract :

Early diagnosis of AKI currently depends on detection of reduced kidney function by the rise in serum creatinine concentration, which is a delayed and unreliable measure in the acute setting. The lack of specific biomarkers for early recognition of AKI has meant a delayed onset of treatment. NGAL fulfils many of the characteristics important for a useful AKI biomarker. NGAL represents a significant component in the pathophysiology of the disease. The concentration of NGAL in urine or plasma rises rapidly in a dose-dependent manner that is proportional to the degree of damage. Aims and objectives Assessing efficacy of NGAL as a marker of early development of acute kidney injury in adult ICU patients and compare among AKI and NON-AKI patients. Method It is a hospital based prospective study of 53 patients, which is conducted at SREE BALAJI MEDICAL COLLEGE CHENNAI. The material for study is formed by adult patients admitted to adult ICU. Between DECEMBER 2016 – AUGUST 2018 fulfilling the inclusion and exclusion criteria. Conclusion Our study demonstrated that admission blood NGAL measurements are useful in early diagnosis of AKI.