Effects of Sidaguri (Sida rhombifolia L) on Uric Acid and C-Reactive protein (CRP) in Patients with Gouty Arthritis

Blondina Marpaung; Jelita Siregar

Volume : VII, Issue : IX, September - 2018

Effects of Sidaguri (Sida rhombifolia L) on Uric Acid and C-Reactive protein (CRP) in Patients with Gouty Arthritis

Blondina Marpaung, Jelita Siregar

Abstract :

Introduction:Gouty arthritis is a metabolic disease associated with a high diet of purines and alcohol consumption. Monosodium urate crystal accumulation (MSU) in joints and soft tissues is the main trigger of inflammation in gouty arthritis. This disease can adversely affect the quality of life of the patient. Increased levels of uric acid in the blood (hyperuricemia) is the main cause of gouty arthritis. One of the medicinal plants is sidaguri (Sida rhombifolia L), has been known to have the potential of antigout and anti-inflammatory activities by inhibiting nitric oxide.

Method:This randomized controlled trial was conducted in Adam Malik Hospital and Prof. Dr. Boloni Hospital Medan from April- October 2018. Patients randomized to receive Sidaguri extract (Sida Rhombifolia L) and meloxicam or placebo andmeloxicamin a double-blind technique.Sample size of each of group was 20 patients.Data were statistically analyzed.

Result:40 Gouty arthritis patients divided into 2 groups: Sidaguri group (20 patients) and Placebo group (20 patients). Based on the T-dependent test, there was significant differences of uric acid and CRP serum before and after treatment between Sidaguri group and Placebo group in Gouty arthritis patients (p=0.0001).

Conclusion: There was significant differences between uric acid levels and CRP before and after treatment of Sidaguri.