Effect of Multigenerational Undernutrition on the Haematological Profile of Adult Wistar Rats

M.M. Karandikar; S.M.Vaidya; K.G.Apte

Volume : V, Issue : VII, July - 2016

Effect of Multigenerational Undernutrition on the Haematological Profile of Adult Wistar Rats

M. M. Karandikar, S. M. Vaidya, K. G. Apte

Abstract :

It has been suggested that diseases like hypertension, diabetes and coronary heart disease arise due to under nutrition in fetal life. We evaluated the effect of undernutrition on blood counts. Total leukocyte count (6.77 vs. 11.52 x 103/ μL; p<0.0001, n=6, U vs. C) was significantly lower in the undernourished colony, MCV (60.05 vs.55.30 μm3; p<0.001, n=6, U vs. C) was higher but MCHC (27.50g/dl vs. 29.28g/dl; p<0.001, n=6, U vs. C) was lower in the undernourished colony. Platelet count (803.0 vs. 414.5 x 103/microliter, p<0.0001, n=6, U vs. C),Platelet distribution width (15.03 vs. 6.25 p<0,0001,n=6,U vs. C) and Platecrit (0.53 vs. 0.25,p<0.0001,n=6,U vs. C)were all higher in the undernourished colony. This is indicative of macrocytic anaemia, an inflammatory process and platelet anisocytosis and increased platelet mass.