EFFECT OF MAGNESIUM SULPHATE VIA INHALATIONAL AND INTRAVENOUS ROUTE IN COPD PATIENTS ON VENTILATOR

RAJEEV PURI; TRILOK CHAND; KAVITA AHUJA; ANAMIKA MISHRA; SHAILENDRA CHAK

Volume : VIII, Issue : I, January - 2019

EFFECT OF MAGNESIUM SULPHATE VIA INHALATIONAL AND INTRAVENOUS ROUTE IN COPD PATIENTS ON VENTILATOR

Rajeev Puri, Trilok Chand, Kavita Ahuja, Anamika Mishra, Shailendra Chak

Abstract :

Magnesium as a onchodilator has a well established role in exacerbation of asthma however it is generally not used in exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Aim of this research was to study the effect of magnesium sulphate given via inhalational and intravenous (IV) route in COPD patients on mechanical ventilation COPD patients admitted to ICU on ventilator support were divided in three groups: (IV Group)- 20 min Intravenous infusion of magnesium sulphate 1gm dissolved in 100ml of 0.9% saline solution along with nebulisation with salbutamol (2.5 mg in 5ml). (Neb Group) Nebulised salbutamol (2.5mg in 2.5ml normal saline) + 2.5ml magnesium sulphate (1gm in 2.5ml normal saline) + 20min intravenous infusion of isotonic saline. (Control Group) Nebulised salbutamol (2.5mg in 2.5ml normal saline) + 2.5ml normal saline + 20min intravenous infusion of isotonic saline. The patients were monitored for peak inspiratory pressure, mean airway pressure every 5 min for half an hour after drug administration everyday. Patients were followed for weaning and total duration of mechanical ventilation requirement was noted. Fall in peak inspiratory pressure was remarkably higher in IV group (19.79 %) as compared to NEB group (12.21%) and control (10%). Similarly, mean airway pressure fall in IV group , NEB group and control group was (19.86%, 16.1% ,15%) respectively . Initiation of ventilation and weaning was also early in IV group followed by NEB and control group respectively. So to conclude MgSO4 given by I/V route was more effective than nebulisation route and supplement Mg either by I/V or nebulization route had a beneficial effect over isolated salbutamol in COPD patients on ventilator.