EFFECT OF DEXMEDETOMIDINE ON CHANGES IN INTRAOCULAR PRESSURE FOLLOWING SUCCINYLCHOLINE AND ENDOTRACHEAL INTUBATION

Dr. Meher Shikha Verma; Dr Neeraj Narang

Volume : VII, Issue : IV, April - 2018

EFFECT OF DEXMEDETOMIDINE ON CHANGES IN INTRAOCULAR PRESSURE FOLLOWING SUCCINYLCHOLINE AND ENDOTRACHEAL INTUBATION

Dr. Meher Shikha Verma, Dr Neeraj Narang

Abstract :

Aims & Objectives: The aim of this study is to evaluate the efficacy of dexmedetomidine premedication for prevention of rise in IOP and effect on hemodynamic response following administration of succinylcholine and endotracheal intubation.

Methodology: In this study 60 patients were randomly allocated into two groups of 30 patients. Group D (Dexmedetomidine): 0.4 mcg/kg/hr. Dexmedetomidine IV infusion over a period of 10 min. Group C (Control): Similar volume and rate of infusion of saline. Intra Ocular Pressure (IOP), Heart rate (HR), Systolic BP (SBP), and Diastolic BP (DBP) were recorded at predefined time intervals from T1 to T8.

Results: There was no significant difference at the baseline IOP in both the groups. After succinylcholine and intubation in Group D there was significant fall in IOP as compared to Group C (P<0.0001). In Group D there was significant fall in Heart rate (P<0.05) and MAP (P<0.0001) as compared to group C.

Conclusion: Dexmedetomidine premedication (0.4μg/kg) effectively prevents the rise of IOP after succinylcholine and endotracheal intubation, causes fall in IOP, HR, SBP, DBP and MAP and cause attenuation of pressor response after succinylcholine, laryngoscopy and endotracheal intubation.