Effect of cigarette smoking on renal function in healthy male subjects, a cross-sectional analytical study

Dr. Abhishek Patil; Dr. Alpana Raizada; Dr. Sunil Agarwal; Dr. Amitesh Aggarwal; Dr. Ashok K Tripathi; Dr. Omprakash Kalra

Volume : VIII, Issue : IV, April - 2019

Effect of cigarette smoking on renal function in healthy male subjects, a cross-sectional analytical study

Dr. Abhishek Patil, Dr. Alpana Raizada, Dr. Sunil Agarwal, Dr. Amitesh Aggarwal, Dr. Ashok K Tripathi, Dr. Omprakash Kalra

Abstract :

Background: The increasing prevalence of chronic kidney disease (CKD) necessitates identification of all the possible risk factors. We conducted this study to determine the effect of smoking on renal function in healthy adults. Methods: The study consisted of 40 healthy male subjects aged 31-40 years in each of the two groups: non-smokers and smokers (cigarettes only). The estimated glomerular filtration rate (eGFR) was calculated by the CKD-EPI equation (Chronic Kidney Disease Epidemiology Collaboration), and the urinary albumin creatinine ratio (ACR), was measured by nephelometry. Results: The mean eGFR in non-smokers was 110.7�9.6 mL/min/1.73m2 and 110.7�9.4 mL/min/1.73m2 in smokers (p=0.999). Mean urinary ACR was significantly (p<0.001) higher in smokers (14.55�8.08 mg/g) as compared to non-smokers (7.96�2.86 mg/g). Further within smokers, there wasa positive correlation between pack years of smoking and urinary ACR values (r=0.858, p<0.001) Conclusion: Cigarette smoking was associated with significantly higher urinary ACR in healthy young males.