Effect of Chronic Exposure of Ibuprofen on Cardiac Muscle of Swiss Albino Mice.

Shweta S. Talhar; Aditya M. Tarnekar; Bharat R. Sontakke; Jwalant E. Waghmare; Moreshwar R. Shende

Volume : VIII, Issue : II, February - 2019

Effect of Chronic Exposure of Ibuprofen on Cardiac Muscle of Swiss Albino Mice.

Shweta S. Talhar, Aditya M. Tarnekar, Bharat R. Sontakke, Jwalant E. Waghmare, Moreshwar R. Shende

Abstract :

Context: Adverse effects of Ibuprofen on liver, gastrointestinal tract, kidneys, are well documented in the literature. The present study was carried out with the aim to investigate the effect of Ibuprofen on Cardiac Muscle of Swiss Albino Mice. Methods: Fifty adult Swiss albino mice grouped as 25 controls and 25 experimental were used for the experimental purpose. Control group was treated with distilled water & experimental group with Ibuprofen suspension given orally in the dose of 40mg/kg/day for 6 weeks. After sacrificing and careful dissection of mice, hearts were removed and processed for routine histological tissue procedures. Results: There occurred significant loss of body weight in experimental mice as compared to controls. Increased weight of heart was observed in experimental mice. Mean diameter of cardiac myocyte was statistically increased in experimental group (p=0.0001, t=8.28). We found significantly reduced volume proportion of cardiac myocytes versus stroma in experimental mice. Conclusions: Ibuprofen, most widely prescribed NSAID, should be used minimally and in lowest possible dose in patients with pre-existing cardiovascular disorders because of its association with cardiovascular events.