Differentiation of focal hepatic lesions into benign and malignant using Diffusion Weighted MR Imaging

Dr Hashim P I; Dr Balutkar Sachin D

Volume : VIII, Issue : IX, September - 2019

Differentiation of focal hepatic lesions into benign and malignant using Diffusion Weighted MR Imaging

Dr Hashim P I, Dr Balutkar Sachin D

Abstract :

Aim: To differentiate benign and malignant hepatic lesions using diffusion weighted MRI. Methods: 82 patients detected to have focal hepatic lesions on USG, CT, MRI or PET were retrospectively analysed. Final diagnosis was confirmed by histopathology, cytology, radiological features, clinical history or follow up. The patients underwent MRI in a 1.5 T unit and Apparent Diffusion Coefficient(ADC) values were calculated. ADC values were analysed using Receiver operative characteristic(ROC) curves to calculate threshold ADC value. Test of Least Significant Difference(LSD) was applied to find out if the difference in mean ADC values of benign and malignant lesions was statistically significant or not. Results: Out of 82 patients, 48 had benign and 34 had malignant lesions. Mean ADC value of 1.68x10-3 mm2/s was found to have the highest sensitivity and specificity for differentiating between benign and malignant lesions. Conclusions: Mean ADC value of 1.68x10-3 mm2/sec has the highest sensitivity and specificity for differentiating between benign and malignant lesions and is recommended as the threshold value.