Diagnostic and prognostic importance of CBC parameters in early Dengue infection: A study of 50 cases in Tertiary Teaching Medical Colleges

Parshuram Prasad; Dr. Subhash Chandra Jha; Vijay Kumar Singh

Volume : VIII, Issue : XI, November - 2019

Diagnostic and prognostic importance of CBC parameters in early Dengue infection: A study of 50 cases in Tertiary Teaching Medical Colleges

Parshuram Prasad, Dr. Subhash Chandra Jha, Vijay Kumar Singh

Abstract :

Background: Aim of study was to determine diagnostic and prognostic importance of change in CBC parameters of NS1+ dengue patients. Certain change in TLC, DLC and HCT parameters could signify dengue infection in feile patients. Further serial CBC findings could predict future course of disease.Dengue viruses (DV) belong to family Flaviviridae and there are four serotypes of the virus referred to as DENV-1, DENV-2, DENV-3 and DENV-4. All four serotypes can cause the full spectrum of disease from a subclinical infection to a mild self limiting disease, the dengue fever (DF) and a severe disease that may be fatal, the dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS).It is epidemic in urban areas of Bihar.. Material and methods: Epidemiological data and hematological parameters of 50 NS1 positive early dengue fever patients were collected during epidemic period of July 2019 to October 2019 in tertiary teaching government medical colleges of Bihar, India Result: Out of total number of 50 patients, female was 18 and male was 32, male female ratio was 1.8:1. Minimum age was 5 years and maximum age was 64 years.TLC was either normal or decreased, predominantly normal, low TLC was in 18 patients and rest has normal TLC . .Differential showed usually normal neutrophil count or neutrophilia, 17 patients had neutrophilia and 1 had neutropenia 5 patients revealed neutropenia with lymphocytosis and monocytosis. Platelet count was usually normal range except thrombocytopenia in five patients, one had<1,00,000/�L. Conclusion: The study results were relevant in the characterization of biological markers in the evolution of the disease and could be used as markers for early diagnosis and prognosis prediction thereby enabling health professionals in taking early help with the adaption of therapeutic conduct for specific patients.