DEVELOPMENT AND TESTING OF NEW HERBAL OINTMENT FOR THE TREATMENT OF STRESS URINARY INCONTINENCE-A PRELIMINARY STUDY

Orescanin Visnja; Findri Gustek Stefica

Volume : V, Issue : VII, July - 2016

DEVELOPMENT AND TESTING OF NEW HERBAL OINTMENT FOR THE TREATMENT OF STRESS URINARY INCONTINENCE-A PRELIMINARY STUDY

Orescanin Visnja, Findri Gustek Stefica

Abstract :

The purpose of this work was development, formulation and testing of new herbal ointment for the treatment of stress urinary incontinence and its related symptoms. 50 women in the age range from 36 to 73 years were treated 8 weeks with vaginal ointment (2 g/day) which consisted of the following ingredients: oil macerates of the plants Capsella bursa-pastoris, Urtica diodica, Quercus robur, Quercus infectoria, Corylus avellana, Ocimum basilicum, Salvia officinalis, Achillea millefolium, Calendula officinalis, Matricaria chamomilla, Hypericum perforatum, Alchemilla vulgaris, Thymus serpyllum, Plantago major, Symphytum officinale; essential oils of the plants Melaleuca alternifolia, Cymbopogon martinii, Cinnamomum camphora ct. cineol, Eugenia caryophylata, Thymus vulgaris ct. tymol, Origanum vulgare; honey; glycerin and Cera flava. The degree of incontinence and its impact on the quality of life prior and after the therapy was assessed by the International Consultation on Incontinence Questionnaire - Urinary Incontinence Short Form (ICIQ-UI SF), where maximum score of 21 represents permanent incontinence and 0 no leakage of urine. Sexual gratification was assessed by the Pelvic organ prolepses / urinary Incontinence / Sexual Questionnaire (PISQ-12). The variables with the highest, statistically significant influence onto degree of incontinence and its impact on the quality of life were were Urine leak and related symptoms, Menopause, Frequent urinary tract infections, Age and Number of childbirth. Significant improvement concerning both, incontinence (p<0.0001) and sexuality (p<0.0003) was observed following two weeks of the application. In the end of the study the mean value of ICIQ-UI score decreased from 10.3�4.2 to 1.1�1.0 while PISQ-12 increased from 21.0�2.9 to 28.4�3.2. Following the eight weeks of the therapy 66% of the patients were completely dry, while other 34% exhibited only slight problems (ICIQ-UI score range 1-3). After only 7 days of the application the symptoms like burning, vaginal discharge, vaginal dryness and painful sexual intercourse decreased significantly while in the end of the treatment disappeared completely