Correlation of NFKB and adiponectin levels with HOMA-IR in patients with gestational diabetes mellitus.

Abha Rathore; Prabhat; Jayashree Bhattacharjee; Manisha Kumar

Volume : VIII, Issue : II, February - 2019

Correlation of NFKB and adiponectin levels with HOMA-IR in patients with gestational diabetes mellitus.

Abha Rathore, Prabhat, Jayashree Bhattacharjee, Manisha Kumar

Abstract :

Objective: To investigate the correlation of serum Tumor Necrosis Factor α (TNF-α), and Adiponectin (ADP) with insulin resistance index (HOMA-IR) in patients with Gestational Diabetes Mellitus (GDM) and to analyze the relationship between the levels of TNF-, TNFR1 as well as ADP during pregnancy period and adverse pregnancy outcomes as well as postpartum progression to type 2 diabetes mellitus (T2DM). Method: A total of 100 pregnant women who received regular prenatal examination in our hospital from January 2017 to September 2017 were selected as the research objects, among whom 50 patients diagnosed with gestational diabetes mellitus were set as patient group with other 50 normal pregnant women as control group. The selected patients were examined on Fasting Plasma Glucose (FPG), Fasting Serum Insulin (FINS). HOMA-IR calculated by formula, which was followed by the analysis on the correlations of HOMA-IR with various indexes, of pregnancy outcome with serum index and of postpartum progression to T2DM with serum index. Serum adiponectin and NFB was estimated by manual ELISA method. Results: Compared with the control group, the levels of FPG, FINS, LDL, HOMA-IR were significantly increased while adiponectin in patient group. Multivariate Logistic regression analysis showed: in patient group, the levels of FPG, FINS, HbAlc, TG, HDL, LDL, TNF-a and TNFR1 showed a positive correlation with HOMA-IR. ADP showed a significant negative correlation with HOMA-IR. The adverse pregnancy outcome was positively correlated with HOMA-IR, TNF-a and TNFR1 while negatively correlated with ADP. The postpartum progression to T2DM was positively correlated with HOMA-IR while negatively correlated with ADP. Conclusion: In patients with gestational diabetes the levels of TNF- are relatively high and ADP level moderately low, which is closely related with insulin resistance.