CORRELATION OF HEMATOLOGIC PARAMETERS WITH SERUM ALBUMIN AND CHOLESTEROL LEVELS IN CHILDREN WITH NEPHROTIC SYNDROME

Dini Zuriana; Oke Rina Ramayani; Yazid Dimyati

Volume : VII, Issue : VII, July - 2018

CORRELATION OF HEMATOLOGIC PARAMETERS WITH SERUM ALBUMIN AND CHOLESTEROL LEVELS IN CHILDREN WITH NEPHROTIC SYNDROME

Dini Zuriana, Oke Rina Ramayani, Yazid Dimyati

Abstract :

Background: Pediatric nephrotic syndrome (NS) is the most common kidney disorder in children. The diagnosis of NS is established by clinical abnormalities, characterized by proteinuria, hypoalbuminemia, edema, and as well as hypercholesterolemia. Regarding the examination of hematologic parameters in patients with NS, one can recognize the risk of infection, and thromboembolism.

Objective: To assess the correlation between hematologic parameters with serum albumin and cholesterol levels in patients with NS.

Method: This was a cross-sectional study conducted at Haji Adam Malik Hospital, Medan, North Sumatera. The study was conducted on Feuary 1^st, 2017 until December 1^st, 2017 with total sample of 65 children with NS. Inclusion criteria was all patient SN whose age 2 until 18 years withhypoalbuminemia and hypercholesterolemia, did not have severe malnutrition, liver function was normal, remission NS was excluded. There were 49 children who included. Pearson and Spearmancorrelation test were used to evaluate which one was required.

Results: There were 31 boys and 18 girls. 43% of children were well-nourished and 6% of children were moderate malnourished. Patients with relapsing NS were 37.7% and patients with SN steroid resistance NS were 63.26%. There were 3 types of hematologic parameters that correlates with serum albumin levels; it were leukocytes (r = -0.29; P = 0.044), platelets (r = -0.23; P = 0.047), ESR (r = - 0.29 ; P = 0.039). The hematologic parameter that correlates with cholesterol levels was platelets (r = 0.44; P = 0.001).

Conclusion: There was a weak negative-correlation between leukocytes, platelets, and erythrocytes sedimentation rate with albumin. There was a moderate negative-correlation between platelets and cholesterol. There were means with examination of hematologic paramaters we can recognize the risk of infection, and thromboembolism in patient with NS.