Contrast Induced Nephropathy In Patients Undergoing Coronary Interventions (ongoing study)

Sharma Mukesh; Choudhary Lekharaj; Ameta Deepak; Jain Mahesh

Volume : IX, Issue : VII, July - 2020

Contrast Induced Nephropathy In Patients Undergoing Coronary Interventions (ongoing study)

Sharma Mukesh, Choudhary Lekharaj, Ameta Deepak, Jain Mahesh

Abstract :

Background: One of the important cause of hospital-acquired acute kidney injury is Contrast induced nephropathy and it affects between 2% of the general population to 50% of high-risk subgroups following coronary intervention. Objectives: To evaluate the incidence of contrast induced nephropathy (CIN), and to study the association of various risk factors with CIN in our population. Methodology: A total of 500 patients (348 males and 152 females) who received nonionic iso-osmolar contrast media during percutaneous coronary intervention (PCI) were enrolled in our study. CIN was deﬁned as a relative increase of 25% or an absolute increase of >0.5 mg/dl in serum creatinine levels two days post procedure. Results: The overall incidence of CIN in our study was 18.8% .In univariate analysis: age >75 years, hypotension, diabeties mellitus, heart failure, CKD [creatinine >1.5mg/dl] and increased contrast volume associated with a trend towards risk of CIN whereas gender and anemia failed to show any statistically signiﬁcant association with CIN. As Mehran�s risk score (MRS) or number of associated risk factors and volume of contrast used increases, the incidence of CIN increases. The incidence of CIN in our study for low, intermediate, high and very high risk groups based on MRS was 17.76%, 13.89%, 30.61% and 41.17% respectively. Conclusion: CIN has association with many risk factors, in our study we found that whenever multiple risk factors or MRS >10 are present in an individual patient, lowest dose of contrast should be used by using �maximal allowable contrast (MAC) dose� to prevent the occurrence of CIN.