Comparison the Effect of Combination Sambiloto Extract (Andrographis paniculata (Burm.f.) Nees) and Salam (Syzygium polyanthum (Wight) Walp) with Simvastatin on Apo-B Concentration in Dyslipidemia Patients

Andri Sunata; Dharma Lindarto; Santi Syafril

Volume : VII, Issue : XI, November - 2018

Comparison the Effect of Combination Sambiloto Extract (Andrographis paniculata (Burm.f.) Nees) and Salam (Syzygium polyanthum (Wight) Walp) with Simvastatin on Apo-B Concentration in Dyslipidemia Patients

Andri Sunata, Dharma Lindarto, Santi Syafril

Abstract :

Background : Dyslipidemia is risk factor of cardiovascular disease and significantly correlated with increased Apo-B concentration. Simvastatin, a sintetic antidyslipidemic drug,can decreaseApo-B concentration. But long term use of sintetic drug may cause side effects, so that phytopharmaca is begin to reuse. Combination sambiloto extract and salam could decrease cholesterol, triglyceride, and proinflammatory cytokines. Aim of this study was to compare the effect of combination sambiloto extract and salam with simvastatin onApo-B concentration in dyslipidemic patients. Method : This clinical trial use prospective design. Study group (n = 15) and control group (n = 15) were choosen with double blind random sampling. Before and after 30 days theraphy, blood sample was taken. Data was analysed with SPSS, if p< 0.05 was considered significant difference. Result: Before and after 30 days theraphy was there was insignificant increase of Apo-B in study group(106,93 + 17,56 VS 107,73 + 26,96) mg/dL; p = 0,463); meanwhile significant decrease was there in control group(117,46 + 27,13 vs 101,80 + 30,01) mg/dL; p = 0,001). Apo-B decrease of control group was biger than that of study group, but statistically insignificant (-0,80 + 33,42 vs 15,66 + 16,85) mg/dL; p = 0,0125).Conclusion: Combination sambiloto extract (Andrographis paniculata) and salam (Syzygium polyanthum)2 x @ 150 mg for 30 days not decreased Apo-B concentration than simvastatin 1 x 20 mg, with statistically insignificant.