Comparison of Topical Retinoids Adapalene and Tretinoin in the Treatment of Grade I and II Acne

Dr Apoorva R; Dr Thilak S; Dr Mahesh V

Volume : V, Issue : XI, November - 2016

Comparison of Topical Retinoids Adapalene and Tretinoin in the Treatment of Grade I and II Acne

Dr Apoorva R, Dr Thilak S, Dr Mahesh V

Abstract :

Introduction Acne is a chronic, inflammatory disease of the pilo-sebaceous unit. It is multifactorial. Topical retinoids are widely used in acne and act by reducing sebum production and reducing inflammation. The widely used topical retinoids are Adapalene and Tretinoin. Objectives To compare efficacy of Topical Adapalene 0.1% and Tretinoin 0.04% in the treatment of Grade I and II acne with respect to clinical efficacy and side effects. Subjects and Methods Randomized prospective comparative trial was done over a period of 6 months with 25 patients in each group. Follow up was done at 4 and 8 weeks to assess improvement. Results and Conclusion Better improvement was seen in with Adapalene - 92% subjects had reduction in Grade compared to 76% in Tretinoin. Side effects were more with tretinoin (72%) than Adapalene (32%). Adapalene was a better choice in Grade I and II acne compared to Tretinoin.