COMPARISON OF MATERNAL AND FOETAL OUTCOME IN INDUCTION OF LABOUR BY ORAL AND VAGINAL MISOPROSTOL

Dr SHIWANI; Dr VANI MALHOTRA; Dr SIMITI NANDA; Dr MEENAKSHI CHAUHAN

Volume : V, Issue : IX, September - 2016

COMPARISON OF MATERNAL AND FOETAL OUTCOME IN INDUCTION OF LABOUR BY ORAL AND VAGINAL MISOPROSTOL

Dr Shiwani, Dr Vani Malhotra, Dr Simiti Nanda, Dr Meenakshi Chauhan

Abstract :

Objective:To study the efficacy of oral misoprostol in comparison to vaginal misoprostol for induction of labour. Methods: Hundred Pregnant women with a singleton cephalic presentation at ≥ 37 weeks� gestation, with an indication for induction of labour were divided in oral and vaginal groups alternately. In oral group a tablet of 200 mcg was dissolved in 200 ml tap water in a bottle.. Twenty ml of solution every 2 hours was given until adequate uterine contractions were achieved (subject to maximum of 12 doses). Women in vaginal group were given 25 mcg vaginal misoprostol tablet every 4 hours (subject to maximum of 6 doses). Main outcome measures numbers of women delivered vaginally within 12 hours of the first dose of misoprostol, interval from the start of induction to vaginal delivery, rate of caesarean section, maternal complications and neonatal outcome. Results: 100 women were alternately allotted to two groups, 50 to the oral misoprostol group and 50 to the vaginal misoprostol group. There were no significant differences between the two treatment groups in the primary outcomes: The mean induction to delivery interval was 13.34�6.83 hours in oral group and 11.98�5.93 hours in vaginal group, vaginal birth achieved in 12 hours (oral 27/50 (54.0%) v vaginal 29/50 (58%); P = 0.8403), caesarean section (7/50 (14%) v 6/50 (12%); P = 0.296). There were no significant differences in adverse maternal or neonatal outcomes. Conclusions: It can be concluded from the present study that both oral and vaginal route are effective agents for preinduction cervical ripening which substantially improve the Bishops score and increase the chances of successful labor induction