COMPARISON OF INTRATHECAL DEXMEDETOMIDINE VERSUS BUPRENORPHINE AS ADJUVANT TO BUPIVACAINE IN SPINAL ANAESTHESIA FOR ABDOMINAL HYSTERECTOMY

BASHEER P M A; SAKEER HUSSAIN

Volume : VIII, Issue : IV, April - 2019

COMPARISON OF INTRATHECAL DEXMEDETOMIDINE VERSUS BUPRENORPHINE AS ADJUVANT TO BUPIVACAINE IN SPINAL ANAESTHESIA FOR ABDOMINAL HYSTERECTOMY

Basheer P M A, Sakeer Hussain

Abstract :

Background: The supplementation of local anaesthetics with adjuvants to improve the efficacy of subarachnoid block has been recognized since long. The most preferred drug has been opioids, but newer drugs like dexmeditomidine has also been introduced and investigated as an effective adjuvant. Aim: This study was conducted to evaluate and compare the characteristics of subarachnoid blockade, hemodynamic stability and adverse effects of Intrathecal buprenorphine and intrathecal dexmeditomidine as an adjuvant to 0.5% hyperbaric bupivacaine for abdominal hysterectomy. Materials and Methods: The present study included 80 patients aged between 35- 60 years of ASA Physical Status PS I/II scheduled for elective abdominal hysterectomy surgeries. The patients were randomly allotted to two groups to receive intra thecal 3ml of 0.5% bupivacaine with 60�g of buprenorphine (Group B; n=40) or 3ml of 0.5% bupivacaine with 5�g of dexmeditomidine (Group D; n=40). The onset time to peak sensory level, motor block, sedation, hemodynamic variables, duration of motor block, analgesia and any adverse effects were noted Results: The motor, sensory blockade and time of rescue analgesia were significantly prolonged in dexmeditomidine group (GroupD), compared to buprenorphine group (Group B). The sedation level was higher in Group D compared to Group B. There was no significant difference in hemodynamic variables, and side effect profile Conclusion: Intrathecal dexmeditomidine when compared to intrathecal buprenorphine causes prolonged anaesthesia and analgesia with reduced need for sedation and rescue analgesics.