COMPARISON OF INTRANASAL CLONIDINE VERSUS DEXMEDETOMIDINE AS PREMEDICANT FOR GENERAL ANAESTHESIA IN HEAD AND NECK SURGERIES: A RANDOMISED DOUBLE BLIND STUDY

Dr. Usha Bafna; Dr. Avinash Barpanda; Dr. Satveer Singh Gurjar

Volume : VIII, Issue : II, February - 2019

COMPARISON OF INTRANASAL CLONIDINE VERSUS DEXMEDETOMIDINE AS PREMEDICANT FOR GENERAL ANAESTHESIA IN HEAD AND NECK SURGERIES: A RANDOMISED DOUBLE BLIND STUDY

Dr. Usha Bafna, Dr. Avinash Barpanda, Dr. Satveer Singh Gurjar

Abstract :

Introduction: Alpha-2 agonists such as Clonidine and Dexmedetomidine have emerged as an alternative for premedication in anaesthesia for blunting the stress response of laryngoscopy. Intranasal route has god compliance and adequate absorption of drug. Methods: Seventy four patients posted for head and neck surgeries, of ASA grade I-II were divided into two groups (37 each). Group-A received intranasal clonidine 3mcg/kg and Group-B received intranasal Dexmedetomidine 2mcg/kg. Each drug diluted to 1.5ml with normal saline and given 45min before induction. Perioperative haemodynamic parameters and sedation scores were recorded. Statistical analysis was done. Results: Both groups showed decrease in Heart Rate (HR) and mean arterial pressure (MAP) but group-B had statistically significant lower HR and MAP (p<0.05) and more number of sedated patients. Conclusion: Dexmedetomidine 2mcg/kg intranasal was better sedative premedicant and hemodynamic response suppressor than intranasal clonidine 3mcg/kg during laryngoscopy and intubation without significant side effects.