Volume : VIII, Issue : VII, July - 2019
Comparison of high risk human papilloma virus DNA testing and pap smear cytology for screening of cervical cancer in high risk group of patients
Dr. Kumkum Gupta
Abstract :
Objective: To compare high risk HPV DNA testing and conventional pap smear cytology for screening of cervical cancer in high risk group of patients. Methods: A hospital based prospective, comparative and observational study conducted in department of Obstetrics and Gynecology, Government medical college, Kota on 150 eligible cases who were sexually active between age group 30-65 years. All eligible women underwent Pap‘s smear testing and HPV DNA testing from ecto-cervix and endo-cervix for screening of carcinoma cervix. Result: Out of all 150 cases, 11 cases were positive for HPV DNA testing. Pap‘s smear was positive in 29 cases. ASCUS were 14%, LSIL were 2.67%, HSIL were 2% and SCC 0.66%.all LSIL, HSIL cases were HPV positive and all 21 ASCUS positive cases were HPV DNA test negative. Colposcopy was done in 11 HPV DNA positive cases, we found that 3 were having grade 1 colposcopy and 4 were having grade 2 colposcopy and 4 were having grade 3 colposcopy and all 4 slides were cytological positive (HSIL).colposcopy was done for Pap‘s smear positive cases (ASCUS and higher).Out of 4 LSIL cases, 2 were grade 1 and 2 were grade 2 and all HSIL were showing grade 3 colposcopy. In HPV positive cases, colposcopy was significant in 72.72% cases and in Pap‘s smear positive cases colposcopy was significant in 28.57% cases, we found 3 HPV positive and cytology negative cases. Conclusion: In comparison to conventional Pap‘s smear, HPV DNA test is more superior for detection of missed cervical abnormalities and women diagnosed as HR -HPV DNA positive needs close surveillance and treatment as required.
Keywords :
Article:
Download PDF
DOI : https://www.doi.org/10.36106/gjra
Cite This Article:
COMPARISON OF HIGH RISK HUMAN PAPILLOMA VIRUS DNA TESTING AND PAP SMEAR CYTOLOGY FOR SCREENING OF CERVICAL CANCER IN HIGH RISK GROUP OF PATIENTS, Dr. Kumkum Gupta GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-8 | Issue-7 | July-2019
Number of Downloads : 260
References :
COMPARISON OF HIGH RISK HUMAN PAPILLOMA VIRUS DNA TESTING AND PAP SMEAR CYTOLOGY FOR SCREENING OF CERVICAL CANCER IN HIGH RISK GROUP OF PATIENTS, Dr. Kumkum Gupta GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-8 | Issue-7 | July-2019