Comparison of hemodynamic characteristics with intraperitoneal instillation of levobupivacaine alone versus with intravenous dexmedetomidine in patients

Dr. Arjun Singh

Volume : IX, Issue : IV, April - 2020

Comparison of hemodynamic characteristics with intraperitoneal instillation of levobupivacaine alone versus with intravenous dexmedetomidine in patients

Dr. Arjun Singh

Abstract :

Background: Dexmedetomidine has emerged as an attractive premedication desirable in laparoscopic surgery wherein significant hemodynamic stress response is seen. Aim: To study the effect of intravenous dexmedetomidine along with intraperitoneal instillation of levobupivacaine in patients undergoing laparoscopic cholecystectomy Patients and Methods: This prospective, randomized, double-blind controlled study was conducted on 70 adults of ASA physical status I and II, scheduled for laparoscopic cholecystectomy under general anaesthesia. Patients were randomized to one of the two groups (n= 35 each). Group B received intravenous 10 ml normal saline (NS) over 10 minutes before extubation along with intraperitoneal instillation of 28 mL Levobupivacaine 0.25% with 2ml of normal saline, while groups BD dexmedetomidine 0.5 �g/kg intravenous (IV) in 10 ml normal saline (NS) over 10 minutes before extubation along with intraperitoneal instillation of levobupivacaine to total volume of 30 ml. Hemodynamic variables (heart rate, systolic, diastolic, mean arterial pressure), and SpO2. Results: General characteristics such as age, sex, and ASA status were comparable between both groups (P>0.05). Hemodynamic variables (heart rate, systolic, diastolic, mean arterial pressure), and SpO2 were comparable between both groups. Conclusion: Dexmedetomidine is safe and but has no added advantage in maintaining haemodynamic stability during laparoscopic cholecystectomy.