Comparison of hemodynamic and vascular parameters between patients with CKD and associated hypertension treated with amlodipine and cilnidipine

Dr. Geeta Sheth; Dr. Shahid Ansari

Volume : IX, Issue : I, January - 2020

Comparison of hemodynamic and vascular parameters between patients with CKD and associated hypertension treated with amlodipine and cilnidipine

Dr. Geeta Sheth, Dr. Shahid Ansari

Abstract :

Background: Hypertension is more prevalent in patients with chronic kidney disease (CKD) and has a strong risk of cardiovascular disease. This study was aimed to assess and compare amlodipine with cilnidipine on hemodynamic parameters of central blood pressure and arterial stiffness in patients with CKD on dialysis and with associated hypertension. Methods: This was a prospective study conducted between October 2018 and October 2019. Patients of either sex with CKD on dialysis and with associated hypertension and receiving either amlodipine or cilnidipine were included in the study. Mobil-O-Graph� PWA was used assess peripheral BP, vascular age, augmentation index (AI) and pulse wave velocity (PWV). Results: A total of 87 patients were included (group 1, amlodipine, n=55; group 2, cilnidipine, n=22). The majority of patients were men (n=55). Proportion of patients with normal, average and abnormal vascular age and arterial stiffness was comparable between the treatment groups. However, in amlodipine group, frequency of patients with normal vascular age (42.2% vs 31.8%) was comparatively higher and frequency of patients with average vascular age (32.8% vs 40.9%) was comparatively lower, compared to cilnidipine group. Conclusion: Both amlodipine and cilnidipine showed equal efficacy on hemodynamic parameters of central blood pressure and arterial stiffness in studied population.