Comparison of haematological parameters in untreated & treated Primary hypothyroid patients in Shivamogga district

Dr.Vinit Anand; Dr.Sridevi .V

Volume : V, Issue : IX, September - 2016

Comparison of haematological parameters in untreated & treated Primary hypothyroid patients in Shivamogga district

Dr. Vinit Anand, Dr. Sridevi . V

Abstract :

Background Thyroid hormones have a crucial role in metabolism and proliferation of blood cells. Thyroid dysfunction induces different effects on blood cells such as anaemia, erythrocytosis, leukopenia and thrombocytopenia and in rare cases pancytopenia. It also alters RBC indices. Aims and objectives: To estimate blood cell counts and blood cell indices in newly diagnosed Primary hypothyroid patients and to evaluate the efficacy of the L-thyroxine treatment on the same in Shivamogga population. Materials and methods: We measured Red blood cell count (RBC), White blood cells / Total leukocyte count (TLC), Differential leukocyte count (DLC), platelet (PLT) count, blood cell indices like haemoglobin [Hb] concentration, mean corpuscular volume [MCV], mean corpuscular haemoglobin [MCH], mean corpuscular haemoglobin concentration [MCHC], hematocrit (HCT) / Packed cell Volume (PCV) and Red cell width distribution (RDW) in 100 newly diagnosed Primary hypothyroid patients & compared it with the euthyroid controls. The same patients were revaluated after treatment with L-thyroxine at the end of three months. Statistical analysis was done using independent T test. Pearson�s correlation coefficient test was done to establish the relationships between the parameters. Results: RBC count was significantly decreased in newly diagnosed Primary hypothyroid patients when compared to euthyroid subjects. There was no significant difference in TLC, DLC and Platelet count. Blood cell indices like Hb, MCV, MCH, MCHC and HCT were significantly decreased and RDW was significantly increased when compared with the euthyroid controls. After three months of L-thyroxine treatment, haemoglobin, RBC count, HCT, MCV, MCH, MCHC showed significant increase and there was a decrease in RDW which was statistically significant. Conclusion: Thyroid dysfunction induces varied effects on haematological parameters. In case of patients with unknown haematological dysfunction, they must be evaluated for thyroid hormones