Comparison of Cholesterol Plasma Concentration and Procalcitonin Level As predictor Worsening of Sepsis

Fathur Rahman; Yutu Solihat; Achsanuddin Hanafie

Volume : VII, Issue : X, October - 2018

Comparison of Cholesterol Plasma Concentration and Procalcitonin Level As predictor Worsening of Sepsis

Fathur Rahman, Yutu Solihat, Achsanuddin Hanafie

Abstract :

ICU patients with infection and MODS, measurements of PCT, CRP and cholesterol were measured on day 1, 5 and the last day of ICU admission. PCT and cholesterol values have high sensitivity and specificity in septic patients with MODS This study aims to determine the comparison of cholesterol levels and procalcitonin levels as predictors of mortality in septic patients. The research method used is analytic observational. The study was conducted at the General Hospital of the Department of Anesthesiology and Intensive Therapy of the Faculty of Medicine, University of North Sumatra from June to August 2018. The total samples obtained were 46 sepsis patients. The diagnosis of sepsis is based on the QSOFA criteria assessed when sepsis is established (T0), at 3 days after sepsis (T1), at 5 days after sepsis. From the results obtained showed that there were 46 patients consisting of 30 people (65.3%) and 16 women (34.7%). The average age of patients in this study was 42.39 years the results of the analysis found that a significant relationship between procalcitonin and cholesterol with worsening in sepsis at sepsis was established (T0), at 3 days after sepsis (T1), at 5 days after sepsis (T2) using Pearson correlation (p < 0.05). From the results of the analysis using the ROC curve at T0, T1, and T2 it was found that the area under the ROC curve (AUC) with the percentage of 44.7%, 40.3% and 44.1% respectively (95% CI 26.6% - 62.8%, p = 0.556). In addition, it was also found that there was no correlation between the results of cholesterol levels as a predictor of worsening in septic patients (t<4,06). The diagnostic value of cholesterol levels does not have a good ability to predict worsening in sepsis patients (p> 0.05), whereas procalcitonin can be a gold standard in establishing sepsis but does not have a good relationship as a predictor of worsening in sepsis