COMPARISON OF ANALGESIC EFFICACY OF GABAPENTIN AND PARACETAMOL AS A PRE-EMPTIVE ANALGESIC AGENT.

Dr Ayaskant Sahoo

Volume : VIII, Issue : VIII, August - 2019

COMPARISON OF ANALGESIC EFFICACY OF GABAPENTIN AND PARACETAMOL AS A PRE-EMPTIVE ANALGESIC AGENT.

Dr Ayaskant Sahoo

Abstract :

Introduction: Post operative pain after surgery is a cause of significant morbidity and patient dissatisfaction. In this study we try to compare efficacy between 1 gram acetaminophen oral dose with 300mg oral dose of Gabapentin in controlling post operative pain when administered preoperatively as a method of preemptive analgesia. Material and methods: This study is a prospective, randomized and comparative study conducted at NRI institute of medical sciences, Visakhapatnam between Oct 2016 to October 2017. 90 patients belonging to ASA status I and II of both genders, age group- 18 to 50 years and undergoing surgeries under general anaesthesia lasting less than 2 hours were enrolled for the study. 2 groups out of which Group A received 1gm oral paracetamol and Group B received 300mg of oral Gabapentin. The groups were compared post operatively for pain scores at 30, 60, 90, 120, 150 minute after surgery using visual analogue scale(VAS). Results: The mean VAS scores were 2.78, 4.07, 5.81, 6.36, 6.5 for Group A and 2.18, 3.5, 4.76, 6.04, 6.43 for Group B. Thus pain scores were consistently lesser in Group B than Group A. The time of first rescue analgesia (i.e, Fentanyl) was compared in both the groups. Mean for time of demand for analgesia was 87.34 mins and 100.6 mins in Group A and Group B respectively. P value was 0.05 thus a significantly earlier requirement of rescue analgesia in Group A.