COMPARISON BETWEEN TWO COMMONLY USED EMPERIC ANTIBIOTOC REGIMENS IN NEONATAL SEPSIS

SHEIKH QUYOOM HUSSAIN; JUVERA GUL WANI; ROSHI BAGHAT

Volume : VIII, Issue : XII, December - 2019

COMPARISON BETWEEN TWO COMMONLY USED EMPERIC ANTIBIOTOC REGIMENS IN NEONATAL SEPSIS

Sheikh Quyoom Hussain, Juvera Gul Wani, Roshi Baghat

Abstract :

Background: Neonatal sepsis remains a major cause of morbidity and mortality and warrants the immediate start of appropriate empiric treatment. Thus, this study compared the effectiveness of the 2 antibiotic regimens (cloxacillin–amikacin or cefotaxime–ampicillin) among neonates with late-onset neonatal sepsis. Methods: We conducted a retrospective cohort study comp� mortality between 2 treatment cohorts of very low birth weight neonates with late-onset sepsis, who had received amikacin–cloxacillin or cefotaxime–ampicillin between march 2014 and april 2016. 32 neonates were selected in each group after proper matching. Results: We identified a total of 150 neonates from the hospital�s record. We included 32 neonates each in the amikacin–cloxacillin and cefotaxime–ampicillin groups. Intraventricular hemorrhage, necrotizing enterocolitis, birth weight, and gestational age were significantly associated with mortality (P < 0.05). The risk of mortality was significantly higher in neonates receiving empiric cefotaxime and ampicillin than those receiving amikacin and cloxacillin .Conclusions: In our center, amikacin–cloxacillin combination therapy was associated with lower mortality in very low birth weight neonates with late-onset sepsis compared with cefotaxime–ampicillin therapy.