Comparision of attenuation of Pressor responses to Direct Laryngoscopy and Endotracheal Intubation with Labetalol versus combination of Gabapentin-Labetalol

Dr S. Venugopal; Dr.S.V.Uma Devi

Volume : VII, Issue : XI, November - 2018

Comparision of attenuation of Pressor responses to Direct Laryngoscopy and Endotracheal Intubation with Labetalol versus combination of Gabapentin-Labetalol

Dr S. Venugopal, Dr. S. V. Uma Devi

Abstract :

Background: Administration of general anaesthesia involves direct laryngoscopy and endotracheal intubation which leads to various physiological stress responses which in turn increases blood pressure and heart rate. These pressor responses may lead to complications in elderly patients and patients with severe systemic diseases. Hence a premedication agent is advocated which can suppress such pressor responses. In this study we compared effect of labetalol and combination of gabapentin-labetalol with a placebo group for attenuation of pressor responses to laryngoscopy and intubation.

Methods: 60 patients belonging to ASA class I and II were divided into three groups A, B and C. One hour before induction of anaesthesia patients in group A received labetalol 100 mg and in group B received 400 mg of gabapentin plus 50 mg of labetalol orally while patients in group C didn�t received any drug and acted as control. Mean arterial pressure (MAP) and heart rate (HR) were recorded in all the three groups at baseline and at 0, 1, 3, 5 and 10 minutes after tracheal intubation.

Results: All the three groups were comparable with regards to demographic characteristics. The baseline HR and MAP was also comparable in all the three groups and was statistically insignificant. However after tracheal intubation there was significant increase in HR and MAP in the control group A and group C whereas in group B the response was attenuated. Among the study groups blood pressure was better attenuated by gabapentin + labetalol combination whereas labetalol alone didn�t abolish the pressor response.

Conclusion: Gabapentin and Labetalol used in combination attenuate the pressor response to laryngoscopy and intubation but labetalol alone was not able to abolish it